PEN2 rabbit pAb - ES14162

PEN2 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES14162-50, ES14162-100

Citations, Manuals and MSDS Available upon request.

Background: Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],

Source: Rabbit

Applications: IHC; IF

Dilution: IHC-p 1: 50-200

Reactivity: Human; Mouse; Rat

Immunogen: Synthesized peptide derived from human PEN2 AA range: 51-101

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Human Gene ID: 55851

Human SWISS Prot NO: Q9NZ42

Subcellular Location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus Golgi stack membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Predominantly located in the endoplasmic reticulum and in the cis-Golgi.

Research Use Only