PEN2 Rabbit Polyclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA28669-50, RA28669-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013], Reactivity: Human, Mouse, Rat Host: Rabbit Applications: IHC-p, IF (paraffin section) Clonality: Polyclonal Dilution: IHC-p 1：50-200 Storage: -20°C/1 year Human Gene ID: 55851 Human SwissProt Number: Q9NZ42 Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Research Use Only