PEN2 Rabbit Polyclonal Antibody - RA28669

PEN2 Rabbit Polyclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA28669-50, RA28669-100 Citations, Manuals and MSDS Available upon request. Background: Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2) . Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013], Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions: -20°C/1 year Recommended dilutions: IHC-p 1：50-200 Applications: IHC-p; IF (paraffin section) Species Cross-Reactivity: Human; Mouse; Rat GeneID (Human): 55851 SWISS: Q9NZ42 Source: Rabbit Research Use Only