Product Description

PER2/Period circadian protein 2 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS65878-50, BS65878-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: PER2, a mammalian homologue of the Drosophila period gene, shares a 40% homology with PER1 including the protein dimerization PAS domain. PER2 is a circadian regμlator that may act as a transcription factor. It behaves as a negative element in circadian transcriptional loop. PER2 does not appear to bind DNA, suggesting indirect transcriptional inhibition. Expression oscillates with a 24 hour rhythm in the suprachiasmatic nucleus (SCN) and the whole eyes. Oscillations are maintained under constant darkness and are responsive to changes of the light/dark cycles. There is a 4 hour time delay between PER1 and PER2 oscillations. The expression rhythms appear to originate from retina.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat, Dog, Cow, Horse

Host: Rabbit

Applications: IHC-P

Alternate Names: Circadian clock protein PERIOD 2, FASPS, hPER 2, hPER2, KIAA0347, PER 2, PER2, Period 2, Period 2 isoform 1, Period circadian protein 2, Period circadian protein homolog 2, Period homolog 2, Period2, FASPS, PER2_HUMAN.

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH conjugated synthetic peptide derived from human PER2:751-850/1225

Dilution: IHC-P=1:100-500

Purification: affinity purified by Protein A

Specificity: PER2/Period circadian protein 2 Polyclonal Antibody detects endogenous levels of PER2/Period circadian protein 2 protein.

Molecular Weight: ~138 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -51°C long term. Avoid freeze-thaw cycles.

SwissProt: O15055

Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Research Use Only