Product Description

PER2 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS66168-50, BS66168-100

Product: PBS with 0.01% thiomersal,50% glycerol,pH7.3.

Swiss-Prot: O15055

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC ChIP,

All Applications: WB: 1:500-1:1000
IHC: 1:50-1:200
ChIP: 1:50-1:200

Background: This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers and have been linked to sleep disorders.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: PER2 polyclonal antibody detects endogenous levels of PER2 protein.

Bioworld Molecular Weight: ~ 136 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of extracts of Mouse liver, using PER2 antibody at 1:1000 dilution., Immunohistochemistry of paraffin-embedded human thyroid cancer using PER2 Rabbit pAb at dilution of 1:100 (40x lens)., Chromatin immunoprecipitation analysis of extracts of MCF7 cells, using PER2 antibody and rabbit IgG.

Alternative Name: PER2; FASPS; FASPS1

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 390-565 of human PER2 (NP_073728.1).

Conjugate: Unconjugated

Modification: Unmodified