Product Description

PER2 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: GCP101-50, GCP101-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Biological timepieces called circadian Clocks are responsible for the regμlationof hormonal rhythms, sleep cycles and other behaviors. The superchiasmaticnucleus (SCN), which is located in the brain, was the first mammalian circadian Clock to be discovered. A number of transcription factors appearing to bemolecμlar components of the SCN Clock have been identified. Mutations within the Clock gene increase the length of the endogenous period and cause aloss of rhythmicity of circadian oscillations. Three mammalian period proteins, designated Per1, Per2 and Per3, exhibit circadian rhythyms in the SCN. Duringsubjective night, Per1 and Per2 RNA levels increase in response to light pμlses while Per3 RNA levels show no change in response to light pμlses. Tim, fortimeless, interacts with Per1 as well as Per2, and Tim and Per1 negativelyregμlate Clock-BMAL1-induced transcription.

Category: Primary Antibody

Reactivity: Human, Pig

Host: Rabbit

Applications: WB, IHC

Alternate Names: Period circadian protein homolog 2, hPER2, Circadian clock protein PERIOD 2, PER2, KIAA0347

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodified

Immunogen: Synthetic peptide, corresponding to Human PER2.

Dilution: WB: 1:2000~1:5000
IHC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: PER2 polyclonal antibody detects endogenous levels of PER2 protein.

Molecular Weight: ~ 155 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: O15055

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Research Use Only