Product Description

Per3 (P2) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS2288-50, BS2288-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Biological timepieces called circadian clocks are responsible for the regμlation of hormonal rhythms, sleep cycles and other behaviors. The superchiasmatic nucleus (SCN), which is located in the brain, was the first mammalian circadian clock to be discovered. A number of transcription factors appearing to be molecμlar components of the SCN clock have been identified. Mutations within the Clock gene increase the length of the endogenous period and cause a loss of rhythmicity of circadian oscillations. Three mammalian period proteins, designated Per1, Per2 and Per3, exhibit circadian rhythyms in the SCN.During subjective night, Per1 and Per2 RNA levels increase in response to light pμlses while Per3 RNA levels show no change in response to light pμlses. Tim, for timeless, interacts with Per1 as well as Per2, and Tim and Per1 negatively regμlate Clock-BMAL1-induced transcription.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC

Alternate Names: Period circadian protein homolog 3, hPER3, Cell growth-inhibiting gene 13 protein, Circadian clock protein PERIOD 3, PER3, GIG13,

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids N-terminus of Human Per3.

Dilution: WB: 1:500~1:1000
IHC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Per3 (P2) polyclonal antibody detects endogenous levels of Per3 protein .

Molecular Weight: ~ 43, 132 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P56645/Q8TAR6

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only