Product Description

Perforin 1 Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA28680-50, RA28680-100

Citations, Manuals and MSDS Available upon request.

Background: perforin 1 (PRF1) Homo sapiens The protein encoded by this gene has structural and functional similarities to complement component 9 (C9) . Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008],

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage Instructions: -20°C/1 year

Recommended dilutions: WB 1:500-2000, IHC 1:50-200, ELISA 1:10000-20000

Alternative Names: Perforin-1 (P1) (Cytolysin) (Lymphocyte pore-forming protein) (PFP)

Applications: WB; IHC; ELISA

Species Cross-Reactivity: Human; Rat; Mouse

GeneID (Human): 5551

Protein MW (KDa): 61

SWISS: P14222

Source: Rabbit

Research Use Only