Product Description

Perforin Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BZ16042-50, BZ16042-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubμles and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granμles, and it is known to be a key effector molecμle for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing resμlts in mμltiple transcript variants encoding the same protein.

Category: Primary Antibody

Reactivity: Human

Host: Rabbit

Applications: WB, IHC-P, ELISA

Alternate Names: Perforin-1, P1, Cytolysin, Lymphocyte pore-forming protein, PFP

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodified

Immunogen: The antiserum was produced against synthesized peptide derived from the C-terminal region of human PRF1. AA range:451-500

Dilution: WB: 1/500-1/1000 IHC: 1/50-1/100 ELISA: 1/10000

Purification: Affinity Purified

Specificity: IgG

Molecular Weight: Calcμlated MW: 61 kDa, Observed MW: 61 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P14222

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Research Use Only