Product Description

Periostin Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS91053-50, BS91053-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q15063(Human)

Host: Rabbit

Reactivity: Human

Applications: WB, FC

All Applications: WB:1:500-1:2,000
FC:1:50-1:100

Background: Periostin (PN), also designated osteoblast-specific factor 2 (OSF-2), is a disulfide linked protein originally isolated as a osteoblast-specific factor. Periostin is a secreted protein that binds heparin and functions as a ligand for alpha(V)beta and alpha(V)beta integrins. In preosteoblasts, Periostin acts as a cell adhesion molecule and plays a role in osteoblast recruitment, spreading and attachment. Periostin is mainly detected in lower gastrointestinal tract, aorta, stomach, placenta, uterus and breast tissues but is up-regulated in epithelial ovarian tumors and overexpressed in breast cancer. Expression of Periostin is increased by bone morphogenetic protein (BMP2) and transforming growth factor β 1(TGF β 1). Periostin contains a typical signal sequence, followed by a cysteine-rich domain, a fourfold repeated domain, which shows homology with the insect protein fasciclin, and a C-terminal domain.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: Periostin polyclonal antibody detects endogenous levels of Periostin protein.

Bioworld Molecular Weight: 89 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of Periostin on human placenta tissue lysate using anti-Periostin antibody at 1/1,000 dilution., Fig2:Flow cytometric analysis of 293T cells with Periostin antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black).

Alternative Name: PN, OSF-2, POSTN, OSF2, Fasciclin-I like, MGC119510, MGC119511, OSF 2, OSF-2, OSF2, Osteoblast specific factor 2 (fasciclin I like), Osteoblast specific factor 2, Osteoblast specific factor, Osteoblast-specific factor 2, PDLPOSTN, Periodontal ligament specific periostin, Periostin, Periostin isoform thy2, Periostin isoform thy4, Periostin isoform thy6, Periostin isoform thy8, Periostin osteoblast specific factor, PN, POSTN, POSTN, RP11 412K4.1,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodified