PERK Polyclonal Antibody
Sizes: 60μL, 120μL, 200μL
Catalogue Numbers: E-AB-70363-60, E-AB-70363-120, E-AB-70363-200
Citations, Manuals and MSDS Available upon request.
Abbreviation: PERK
Target Synonym: DKFZp781H1925; E2AK3; EC 2.7.11.1; Eif2ak3; Eukaryotic translation initiation factor 2 alpha kinase 3; Eukaryotic translation initiation factor 2-alpha kinase 3; Heme regulated EIF2 alpha kinase; HRI; HsPEK; Pancreatic eIF2 alpha kinase; Pancreatic eIF2-alpha kinase; PEK; PRKR like endoplasmic reticulum kinase; PRKR-like endoplasmic reticulum kinase; WRS
Research Areas: Cancer, Epigenetics and Nuclear Signaling, Metabolism
Conjugation: Unconjugated
Host: Rabbit
Species Reactivity: Human
Application: IHC
Isotype: IgG
Clonality: Polyclonal
UNIProt ID: Q9NZJ5
Background: The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.
Concentration: 1.4 mg/mL
Immunogen: KLH conjugated Synthetic peptide corresponding to Human PERK
Buffer: PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4
Purification Method: Affinity purification
Dilution: IHC 1:400-1000
Storage: -20°C/One year. Avoid freeze / thaw cycles.
Shipping: Ice bag
Research Use Only