PERK Polyclonal Antibody - RA21188

PERK Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA21188-50, RA21188-100

Citations, Manuals and MSDS Available upon request.

Background: eukaryotic translation initiation factor 2 alpha kinase 3 (EIF2AK3) Homo sapiens The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015],

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage Instructions: -20°C/1 year

Recommended dilutions: IF: 1:50-200 Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

Alternative Names: EIF2AK3; PEK; PERK; Eukaryotic translation initiation factor 2-alpha kinase 3; PRKR-like endoplasmic reticulum kinase; Pancreatic eIF2-alpha kinase; HsPEK

Applications: IF/ICC; WB; IHC-p; ELISA

Species Cross-Reactivity: Human; Mouse; Rat

GeneID (Human): 9451

Protein MW (KDa): 125

SWISS: Q9NZJ5

Source: Rabbit

Research Use Only