Peroxiredoxin 1 Polyclonal Antibody-BS91054

Peroxiredoxin 1 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS91054-50, BS91054-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q06830(Human) P35700(Mouse)

Host: Rabbit

Reactivity: Human, Mouse

Applications: WB, ICC/IF, IHC, FC

All Applications: WB:1:1,000-1:5,000
ICC:1:100-1:500
IHC:1:50-1:200
FC:1:50-1:100

Background: The peroxiredoxin (PRX) family comprises six antioxidant proteins, PRX I, II, III, IV, V and VI, which protect cells from reactive oxygen species (ROS) by preventing the metal-catalyzed oxidation of enzymes. The PRX proteins primarily utilize thioredoxin as the electron donor for antioxidation, although they are fairly promiscuous with regard to the hydroperoxide substrate. In addition to protection from ROS, peroxiredoxins are also involved in cell proliferation, differentiation and gene expression. PRX I, II, IV and VI show diffuse cytoplasmic localization, while PRX III and V exhibit distinct mitochondrial localization. The human PRX I gene encodes a protein that is expressed in several tissues, including liver, kidney, testis, lung and nervous system. PRX II is expressed in testis, while PRX III shows expression in lung. PRX I, II and III are overexpressed in breast cancer and may be involved in its development or progression. Upregulated protein levels of PRX I and II in Alzheimer's disease (AD) and Down syndrome (DS) indicate the involvement of PRX I and II in their pathogenesis. The human PRX IV gene is abundantly expressed in many tissues.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: Peroxiredoxin 1 polyclonal antibody detects endogenous levels of Peroxiredoxin 1 protein.

Bioworld Molecular Weight: 22 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of Peroxiredoxin 1 on different lysates using anti-Peroxiredoxin 1 antibody at 1/1,000 dilution.
Positive control:
Lane 1: Hela
Lane 2: A431, ICC staining Peroxiredoxin 1 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Alternative Name: NKEF-A, PAG, PRDX1, Heme binding 23 kDa protein, MSP23, Natural killer cell-enhancing factor A, NKEF A, NKEF-A, NKEFA, OSF3, Osteoblast specific factor 3, PAG, Paga, PAGB, Peroxiredoxin-1, PRDX1, PRDX1, Proliferation associated gene A, Proliferation-associated gene protein, PRX1, PrxI, TDPX2, Thioredoxin peroxidase 2, Thioredoxin-dependent peroxide reductase 2,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodified