PFKFB1 Polyclonal Antibody - E-AB-13026

PFKFB1 Polyclonal Antibody

Sizes: 60μL, 120μL, 200μL

Catalogue Numbers: E-AB-13026-60, E-AB-13026-120, E-AB-13026-200

Citations, Manuals and MSDS Available upon request.

Abbreviation: PFKFB1

Target Synonym: F6PK; HL2K; PFRX

Research Areas: Cancer, Cardiovascular, Metabolism, Neuroscience, Signal Transduction

Conjugation: Unconjugated

Host: Rabbit

Species Reactivity: Human, Mouse, Rat

Application: IHC, ELISA

Isotype: IgG

Clonality: Polyclonal

UNIProt ID: P16118

Background: This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2, 6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2, 6-biphosphate using independent catalytic domains. Fructose-2, 6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2, 6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene.

Concentration: 0.5 mg/mL

Immunogen: Synthetic peptide of human PFKFB1

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification Method: Affinity purification

Dilution: IHC 1:50-1:200

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only