Product Description

PFKFB2 (phospho-S483) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS4859-50, BS4859-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: PFK-1 undergoes activation in the presence of elevated AMP. The most potent activator is fructose-2, 6-bisphosphate, which is produced by PFK-2 from the same substrate, fructose 6-phosphate. PFK-2 is bifunctional and a key regμlator for PFK-1. PFK-2 catalyzes the synthesis of fructose-2, 6-bisphosphate, and contains fructose-2, 6-biphosphatase activity that catalyzes the degradation of fructose-2, 6-bisphosphate. PFK-2 is dimeric and isoenzymes include PFK-2 liver (PFKFB1, PFRX), PFK-2 cardiac (PFKFB2), PFK-2 placental (PFKFB3, inducible PFK-2) and PFK-2 testis (PFKFB4).

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC

Alternate Names: PFK-2 car, PFK-2 cardiac, 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 2, 6PF-2-K/Fru-2, 6-P2ase 2, PFK/FBPase 2, 6PF-2-K/Fru-2, 6-P2ase heart-type isozyme, 6-phosphofructo-2-kinase, Fructose-2, 6-bisphosphatase, PFKFB2

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Phosphorylation

Immunogen: Synthetic phosphopeptide derived from human PFKFB2 around the phosphorylation site of Serine 483.

Dilution: WB: 1:500~1:1000
IHC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: p-PFKFB2 (S483) polyclonal antibody detects endogenous levels of PFKFB2 protein only when phosphorylated at Ser483.

Molecular Weight: ~ 58 kDa

Pathway: Warburg Effect, Glutamine Metabolism,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: O60825

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only