PFKFB3 Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A6945-20, A6945-100
Citations, Manuals and MSDS Available upon request.
Background: The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2, 6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2, 6-bisphosphate (F2, 6BP), and a fructose-2, 6-biphosphatase activity that catalyzes the degradation of F2, 6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Category: Polyclonal Antibodies
Applications: WB, IHC-P, ELISA
Cross-reactivity: Human, Mouse, Rat
Protein Weight: 60kDa
Observed Molecular Weight: 62kDa
Immunogen: Recombinant protein (or fragment) .
Species: Human
GeneID: 5209
SWISS: Q16875
Alternate Names: PFK2; IPFK2; iPFK-2; PFKFB3
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Recommended Dilutions: WB, 1:100 - 1:500 IHC-P, 1:50 - 1:200 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Endocrine Metabolism, Carbohydrate metabolism, AMPK Signaling Pathway, Warburg Effect.
NCBI Alias: PFKFB3
Research Use Only