Product Description

PGCA (Cleaved-Ala17) Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA28710-50, RA28710-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: alternative products:Additional isoforms seem to exist, developmental stage:Expression was detected in chondrocytes throughout the developing skeleton., disease:Defects in ACAN are the cause of spondyloepiphyseal dysplasia type Kimberley (SEDK) [MIM:608361]. Spondyloepiphyseal dysplasias are a heterogeneous group of congenital chondrodysplasias that specifically affect epiphyses and vertebrae. The autosomal dominant SEDK is associated with premature degenerative arthropathy., domain:Two globular domains, G1 and G2, comprise the N-terminus of the proteoglycan, while another globular region, G3, makes up the C-terminus. G1 contains Link domains and thus consists of three disulfide-bonded loop structures designated as the A, B, B' motifs. G2 is similar to G1. The keratan sulfate (KS) and the chondroitin sulfate (CS) attachment domains lie between G2 and G3., function:This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region., online information:Aggrecan, PTM:Contains mostly chondroitin sulfate, but also keratan sulfate chains, N-linked and O-linked oligosaccharides. The release of aggrecan fragments from articular cartilage into the synovial fluid at all stages of human osteoarthritis is the result of cleavage by aggrecanase., similarity:Belongs to the aggrecan/versican proteoglycan family., similarity:Contains 1 C-type lectin domain., similarity:Contains 1 EGF-like domain., similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain., similarity:Contains 1 Sushi (CCP/SCR) domain., similarity:Contains 4 Link domains., subunit:Interacts with FBLN1., tissue specificity:Restricted to cartilages.,

Reactivity: Human, Rat

Host: Rabbit

Applications: WB, ELISA

Alternate Names: Aggrecan core protein (Cartilage-specific proteoglycan core protein;CSPCP;Chondroitin sulfate proteoglycan core protein 1;Chondroitin sulfate proteoglycan 1) [Cleaved into: Aggrecan core protein 2]

Clonality: Polyclonal

Dilution: WB 1:1000-2000 ELISA 1:5000-20000

Molecular Weight: 240-260

Protein Molecular Weight (kDa): 240-260

Storage: -20°C/1 year

Human SwissProt Number: P16112

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Research Use Only