PGI2 synthase Polyclonal Antibody - BT-AP07100

PGI2 synthase Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP07100-20, BT-AP07100-50, BT-AP07100-100

Citations, Manuals and MSDS Available upon request.

Background: PTGIS (prostaglandin I2 (prostacyclin) synthase) encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis.

Research Areas: Immunology

Target Protein: PTGIS

Applications: WB, ELISA

Reactivity: Human, Mouse, Rat

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: PGI2 synthase Antibody

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Molecular Weight (Da): 57104

UniProt Accession: Human: Q16647; Mouse: O35074; Rat: Q62969

Synonyms: PTGIS; CYP8; CYP8A1; Prostacyclin synthase; Prostaglandin I2 synthase

GeneID: Human: 5740; Mouse: 19223; Rat: 25527

Research Use Only