PGI2 synthase Polyclonal Antibody - RA28713

PGI2 synthase Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA28713-50, RA28713-100

Citations, Manuals and MSDS Available upon request.

Background: prostaglandin I2 synthase (PTGIS) Homo sapiens This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. [provided by RefSeq, Jul 2008],

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage Instructions: -20°C/1 year

Recommended dilutions: Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.

Alternative Names: PTGIS; CYP8; CYP8A1; Prostacyclin synthase; Prostaglandin I2 synthase

Applications: WB; ELISA

Species Cross-Reactivity: Human; Mouse; Rat

GeneID (Human): 5740

Protein MW (KDa): 57

SWISS: Q16647

Source: Rabbit

Research Use Only