PGI2 synthase rabbit pAb - ES6892

PGI2 synthase rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES6892-50, ES6892-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. [provided by RefSeq, Jul 2008],

Alternate Name: PTGIS; CYP8; CYP8A1; Prostacyclin synthase; Prostaglandin I2 synthase

Source: Rabbit

Applications: WB; ELISA; IHC

Dilution: WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000

Reactivity: Human; Mouse; Rat

Immunogen: Synthesized peptide derived from the C-terminal region of human PGI2 synthase.

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 57kD

Human Gene ID: 5740

Human SWISS Prot NO: Q16647

Subcellular Location: Endoplasmic reticulum membrane; Single-pass membrane protein.

Research Use Only