Product Description

PGR Polyclonal Antibody

Sizes: 60μL, 120μL, 200μL

Catalogue Numbers: E-AB-70121-60, E-AB-70121-120, E-AB-70121-200

Citations, Manuals and MSDS Available upon request.

Abbreviation: PGR

Target Synonym: NR3C3; Nuclear receptor subfamily 3 group C member 3; PGR; PR; PRA; PRB; PRGR; Progesterone receptor; Progestin receptor form A; Progestin receptor form B

Research Areas: Cancer, Epigenetics and Nuclear Signaling, Neuroscience, Signal Transduction

Conjugation: Unconjugated

Host: Rabbit

Species Reactivity: Human, Mouse

Application: IHC

Isotype: IgG

Clonality: Polyclonal

UNIProt ID: P06401,Q00175,Q63449

Background: PGR, also named as NR3C3 and PR, belongs to the nuclear hormone receptor family and NR3 subfamily. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation. The ER and PR status has been used as a predictor of breast carcinoma responsiveness to endocrine therapy and as a prognostic indicator for early recurrence.

Concentration: 1.32 mg/mL

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse Progesterone receptor

Buffer: PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4

Purification Method: Affinity purification

Dilution: IHC 1:200-1:800

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only