Product Description

PGRMC2 Polyclonal Antibody

Catalogue Numbers: BS5853-50, BS5853-100

Sizes: 50µl, 100µl

Alternative Name: Membrane-associated progesterone receptor component 2; Progesterone membrane-binding protein; Steroid receptor protein DG6; DG6; PMBP

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: O15173

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB ICC

All Applications: WB: 1:500~1:1000
ICC: 1:50~1:200

Background: PGRMC2 (progesterone receptor membrane component 2), also known as DG6 (steroid receptor protein DG6) or PMBP (progesterone membrane-binding protein), is a single pass membrane protein belonging to the cytochrome b5 family (MAPR (membrane associated progesterone receptor) subfamily). Expressed in sperm, PGRMC2 is believed to function as a steroid receptor and may participate in the progesterone-dependent sperm acrosome reaction. PGRMC2 shares approximately 50% overall sequence identity with its close relative PGRMC1. The loss of the gene encoding PGRMC2 is associated with metastasis in uterine endocervical adenocarcinomas, implicating a potential role of PGRMC2 in the suppression of metastasis of endocervical adenocarcinomas.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: PGRMC2 polyclonal antibody detects endogenous levels of PGRMC2 protein.

Bioworld Molecular Weight: ~ 24 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of PGRMC2 polyclonal antibody at 1:500 dilution
Lane 1: Hela cell lysate
Lane 2: H9C2 cell lysate
Lane 3: Rat brain tissue lysate

Immunogen: Synthetic peptide, corresponding to the 178-223 of Human PGRMC2.

Conjugate: Unconjugated

Modification: Unmodified