PHB2 rabbit pAb - ES11135

PHB2 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES11135-50, ES11135-100

Citations, Manuals and MSDS Available upon request.

Background: developmental stage:Levels of expression in fibroblasts decrease heterogeneously during cellular aging., function:Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging., induction:Expression increases approximately 3-fold upon entry into G1 phase compared to other phases of the cell cycle. Also induced following inhibition of mitochondrial protein synthesis by thiamphenicol., similarity:Belongs to the prohibitin family., subcellular location:Also cytoplasmic and nuclear., subunit:Interacts with PHB, ESR1, HDAC1 and HDAC5.,

Source: Rabbit

Applications: WB; ELISA

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Reactivity: Human; Rat; Mouse

Immunogen: Synthesized peptide derived from part region of human protein

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 32kD

Human Gene ID: 11331

Human SWISS Prot NO: Q99623

Subcellular Location: Mitochondrion inner membrane. Cytoplasm. Nucleus. Cell membrane.; [Isoform 1]: Mitochondrion inner membrane.; [Isoform 2]: Mitochondrion inner membrane.

Research Use Only