PHF17 Polyclonal Antibody-BS8143

PHF17 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS8143-50, BS8143-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q6IE81

Host: Rabbit

Reactivity: Human, Mouse

Applications: WB IF

All Applications: WB: 1:500~1:2000
IF: 1:50~1:200

Background: Jade-1, also known as PHF17 (PHD finger protein 17), is an 842 amino acid protein that localizes to both the cytoplasm and the nucleus and contains two PHD-type zinc fingers. Expressed at high levels in kidney tissue and also present in heart, pancreas and liver, Jade-1 functions as a transcriptional coactivator that, via its PHD zinc fingers, promotes the TIP30-dependent acetylation of Histone H4. Additionally, Jade-1 is thought to promote apoptosis and is down-regulated in renal carcinoma cells, suggesting a possible role in tumor suppression. Three isoforms of Jade-1, two of which are designated JADE1L and JADE1S, are produced via alternative splicing events. The gene encoding Jade-1 maps to human chromosome 4, which encodes nearly 6% of the human genome and has the largest gene deserts (regions of the genome with no protein encoding genes) of all of the human chromosomes.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: PHF17 polyclonal antibody detects endogenous levels of PHF17 protein.

Bioworld Molecular Weight: ~ 108 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western Blot (WB) analysis of PHF17 polyclonal antibody

Alternative Name: Protein Jade-1; Jade family PHD finger protein 1; PHD finger protein 17; JADE1; KIAA1807; PHF17

Immunogen: Recombinant full length Human PHF17.

Conjugate: Unconjugated

Modification: Unmodified