PHKB rabbit pAb - ES6585

PHKB rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES6585-50, ES6585-100

Citations, Manuals and MSDS Available upon request.

Background: Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The beta subunit is the same in both the muscle and hepatic isoforms, encoded by this gene, which is a member of the phosphorylase b kinase regulatory subunit family. The gamma subunit also includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9B, also known as phosphorylase kinase deficiency

Alternate Name: PHKB; Phosphorylase b kinase regulatory subunit beta; Phosphorylase kinase subunit beta

Source: Rabbit

Applications: WB; IHC

Dilution: WB 1:500-2000; IHC-p 1:50-300

Reactivity: Human; Mouse

Immunogen: The antiserum was produced against synthesized peptide derived from human KPBB. AA range:661-710

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 124kD

Human Gene ID: 5257

Human SWISS Prot NO: Q93100

Subcellular Location: Cell membrane; Lipid-anchor; Cytoplasmic side.

Research Use Only