Phosoho-ErbB 2/EGFR (Tyr1248/Tyr1173) Monoclonal Antibody-MB10414

Phosoho-ErbB 2/EGFR (Tyr1248/Tyr1173) Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB10414-50, MB10414-100

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Swiss-Prot: P04626

Host: Rabbit

Reactivity: Human

Applications: WB,IP

All Applications: WB: 1/500-1/1000 IP: 1/20

Background: This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of PhosohoErbB 2 /EGFR in HelaLysates using PhosohoErbB 2/EGFR antibody.

Bioworld Molecular Weight: Calculated MW: 138 kDa; Observed MW: 180 kDa

Specificity: IgG

Alternative Name: ERBB2; HER2; MLN19; NEU; NGL; Receptor tyrosine-protein kinase erbB-2; Metastatic lymph node gene 19 protein; MLN 19; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; Tyrosine kinase-type cell surface receptor HER2; p185erbB2; CD antigen CD340

Immunogen: A synthetic phosphopeptide corresponding to residues surrounding Tyr1248 of human ErbB 2

Conjugate: Unconjugated

Modification: Phosphorylated