Phospho-AIP4 (Y420) Polyclonal Antibody - BT-PHS01072

Phospho-AIP4 (Y420) Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-PHS01072-20, BT-PHS01072-50, BT-PHS01072-100

Citations, Manuals and MSDS Available upon request.

Background: ITCH (itchy E3 ubiquitin protein ligase) encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in ITCH are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for ITCH.

Research Areas: Cell Biology

Target Protein: ITCH

Applications: IHC-p, ELISA

Reactivity: Human, mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Phospho-AIP4 (Y420) Antibody

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Molecular Weight (Da): 102803

UniProt Accession: Human: Q96J02; Mouse: Q8C863

Synonyms: ITCH; E3 ubiquitin-protein ligase Itchy homolog; Itch; Atrophin-1-interacting protein 4; AIP4; NFE2-associated polypeptide 1; NAPP1

GeneID: Human: 83737; Mouse: 16396

Research Use Only