Product Description

phospho-AKT3 (Ser472) Polyclonal Antibody

Size: 100μl

Catalogue Number: BS65910-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Akt, protein kinase B (PKB), is a serine/threonine kinase which is involved in many cellμlar signaling pathways and acts as a transducer of many functions initiated by growth factor receptors that activate phosphtidylinositol 3 kinase (PI 3 kinase). The major activity of Akt/PKB is to mediate cell survival. Akt/PKB is also believed to be a critical factor in the genesis of cancer as the tumor suppressor PTEN was found to antagonise PI3 kinase and Akt/PKB kinase activity. There are 3 known isoforms of this enzyme in mammalian cells (1/alpha, 2/beta and 3/gamma). IGF1 leads to the activation of AKT3, which may play a role in regμlating cell survival. It is capable of phosphorylating several known proteins.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep

Host: Rabbit

Applications: WB

Alternate Names: Akt3, AKT3 kinase, AKT3_HUMAN, DKFZp434N0250, PKB gamma, PKBG, PRKBG, Protein kinase Akt-3, Protein Kinase AKT3, Protein kinase B gamma, RAC gamma, RAC gamma serine/threonine protein kinase, RAC-gamma serine/threonine-protein kinase, RAC-PK-gamma, RACPK Gamma, Serine threonine protein kinase Akt 3, Serine threonine protein kinase Akt3, STK 2, STK-2, STK2, V akt murine thymoma viral oncogene homolog 3 protein kinase B gamma.

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Phosphorylation

Immunogen: KLH conjugated Synthesised phosphopeptide derived from human AKT3 around the phosphorylation site of Ser472:QF(p-S)YS

Dilution: WB=1:500-2000

Purification: affinity purified by Protein A

Specificity: phospho-AKT3 (Ser472) Polyclonal Antibody detects endogenous levels of AKT3 protein only when phosphorylated at Ser472.

Molecular Weight: 56kDa

Pathway: Phosphoinosotode Signaling, Immune Cell Signaling, Warburg Effect, Translational Contral elF4 and p70 S6 Kinase, Insμlin &Glucose Signaling, ErbB HER Signaling,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q9Y243

Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Research Use Only