Phospho-ATP Citrate Synthase (Thr447/Ser451) Monoclonal Antibody-MB10589

Phospho-ATP Citrate Synthase (Thr447/Ser451) Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB10589-50, MB10589-100

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Swiss-Prot: P53396

Host: Rabbit

Reactivity: Human

Applications: WB

All Applications: WB: 1/500-1/1000

Background: ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of Phospho-ATP citrate lyase in K562Lysates using Phospho-ATP Citrate Synthase antibody.

Bioworld Molecular Weight: Calculated MW: 121 kDa; Observed MW: 121 kDa

Specificity: IgG

Alternative Name: ACLY; ATP-citrate synthase; ATP-citrate; pro-S-)-lyase; ACL; Citrate cleavage enzyme

Immunogen: A synthetic phosphopeptide corresponding to residues surrounding Thr447/Ser451 of human ATP citrate lyase

Conjugate: Unconjugated

Modification: Phosphorylated