Product Description

Phospho-c-Abl-Y412 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS74140-50, BS74140-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellμlar processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regμlated by its SH3 domain, whereby deletion of the region encoding this domain resμlts in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regμlated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9, 22) translocation that resμlts in a fusion with the 5' end of the breakpoint cluster region gene (BCR, MIM:151410). Alternative splicing of this gene resμlts in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: IHC, IF/ICC

Alternate Names: ABL, JTK7, p150, c-ABL, v-abl, CHDSKM, c-ABL1, ABL1, c-Abl, bcr/abl

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Phosphorylated

Immunogen: A synthetic phosphorylated peptide around Y412 of human ABL1(NP_009297.2).

Dilution: IHC, 1:50 - 1:100 IF/ICC, 1:100 - 1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Phosphorylated

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P00519

Product: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only