Phospho-CAD (T456) Polyclonal Antibody - BT-PHS01083

Phospho-CAD (T456) Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-PHS01083-20, BT-PHS01083-50, BT-PHS01083-100

Citations, Manuals and MSDS Available upon request.

Background: The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase) encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. Alternative splicing results in multiple transcript variants encoding different isoforms.

Research Areas: Others

Target Protein: CAD

Applications: IHC-p, ELISA

Reactivity: Human, mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Phospho-CAD (T456) Antibody

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Molecular Weight (Da): 242984

UniProt Accession: Human: P27708

Synonyms: CAD; CAD protein

GeneID: Human: 790

Research Use Only