Phospho-Caldesmon (S759) Polyclonal Antibody - BT-PHS01084

Phospho-Caldesmon (S759) Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-PHS01084-20, BT-PHS01084-50, BT-PHS01084-100

Citations, Manuals and MSDS Available upon request.

Background: CALD1 (caldesmon 1) encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.

Research Areas: Signal Transduction; Cardiovascular

Target Protein: CALD1

Applications: IHC-p, ELISA

Reactivity: Human, mouse, rat

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Phospho-Caldesmon (S759) Antibody

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Molecular Weight (Da): high molecular weight (predominantly in smooth muscles) (120-150 KD) and a low molecular weight (60

UniProt Accession: Human: Q05682; Rat: Q62736

Synonyms: CALD1; CAD; CDM; Caldesmon; CDM

GeneID: Human: 800; Rat: 25687

Research Use Only