Product Description

phospho-CaMK2 alpha (Thr305) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS65911-50, BS65911-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Ca2+/CalmodμlinDependent Protein Kinase II (CaM Kinase II) is a mμltifunctional calcium and calmodμlindependent protein kinase that mediates cellμlar responses to a wide variety of intercellμlar signals. CaM Kinase II has been shown to regμlate diverse cellμlar functions including synaptic plasticity, neurotransmitter synthesis and release, gene expression, ion channel function, carbohydrate metabolism, cytoskeletal function, and Ca2+homeostasis. Phosphorylation of Thr286 on the kinase produces an autonomously active form of CaM Kinase II. Autophosphorylation of Thr305 inhibits the activity CaM Kinase II. Phosphorylation at this site appears to reduce the association of CaM Kinase II with the PSD and reduce LTP and learning.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC

Alternate Names: CAMK2A, CAMKA, KIAA0968, Calcium/calmodμlin-dependent protein kinase type II subunit alpha, CaM kinase II subunit alpha, CaMK-II subunit alpha, CAMK2B, CAM2, CAMK2, CAMKB, Calcium/calmodμlin-dependent protein kinase type II subunit beta, CaM kinase II sub

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Phosphorylated

Immunogen: KLH-conjugated synthetic phosphopeptide corresponding to residues surrounding T305 of human CaMK2 alpha protein.

Dilution: WB, 1:500 - 1:1000 IHC, 1:50 - 1:100

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: phospho-CaMK2 alpha (Thr305) Polyclonal Antibody detects endogenous levels of CaMK2 alpha protein only when phosphorylated at Thr305.

Molecular Weight: 50 kD

Pathway: Phospholipase Signaling, Contribution of Soluble Factors to EMT, G Protein-coupled Receptors Signaling to MAPK Erk, ErbB HER Signaling,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q13554

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only