Phospho-FOXO3A (Ser253) Monoclonal Antibody-MB10933

Phospho-FOXO3A (Ser253) Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB10933-50, MB10933-100

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Swiss-Prot: O43524

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB,

All Applications: WB: 1/500-1/1000

Background: FoxO3a is a transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: IgG

Bioworld Molecular Weight: Calculated MW: 71 kDa; Observed MW: 82 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of Phospho-FOXO3A in 3T3 lysates using Phospho-FOXO3A antibody., Western blot analysis of Phospho-FOXO3A in K562, C6 lysates using Phospho-FOXO3A antibody.

Alternative Name: FOXO3; FKHRL1; FOXO3A; Forkhead box protein O3; AF6q21 protein; Forkhead in rhabdomyosarcoma-like 1

Immunogen: A synthetic phosphopeptide corresponding to residues surrounding Ser253 of human FOXO3A

Conjugate: Unconjugated

Modification: Phosphorylated