Product Description

Phospho-HDAC6 (Ser22) Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BZ16326-50, BZ16326-100

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Swiss-Prot: Q9UBN7

Host: Rabbit

Reactivity: Human, Mouse

Applications: WB

All Applications: WB: 1/500-1/1000

Background: Involved in the regulation of many cellular processes, including cell migration, immune synapse formation, viral infection, and degradation of misfolded proteins. HDAC6 binds to both poly-ubiquitinated misfolded proteins and dynein motors, facilitating the transport of misfolded proteins to the aggresome. Required for subsequent recruitment of the autophagic machinery and clearance of aggresomes from the cell. Plays a key role in the protection against the deleterious effects of pathological protein aggregation that occurs in various diseases.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of Phospho-HDAC6 in 3T3Lysates using Phospho-HDAC6 antibody.

Bioworld Molecular Weight: Calculated MW: 131 kDa; Observed MW: 131 kDa

Specificity: IgG

Alternative Name: HDAC6; KIAA0901; JM21; Histone deacetylase 6; HD6

Immunogen: Synthetic peptide of human HDAC6

Conjugate: Unconjugated

Modification: Phosphorylated