Phospho-Histone H2A.X (Ser139) Monoclonal Antibody-MB10958

Phospho-Histone H2A.X (Ser139) Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB10958-50, MB10958-100

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Swiss-Prot: P16104

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IP,

All Applications: WB: 1/500-1/1000 IP: 1/20

Background: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: IgG

Bioworld Molecular Weight: Calculated MW: 15 kDa; Observed MW: 15 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of gamma H2A. X in HepG2 lysates using Phospho-Histone H2A. X antibody., Western blot analysis of gamma H2A. X in Jurkat, THP-1, C6, 3T3 lysates using gamma H2A. X antibody.

Alternative Name: H2A.X; H2AFX; H2a/x; HIST5-2AX; Histone H2A.X; gamma H2A.X

Immunogen: A synthetic phosphopeptide corresponding to residues surrounding Ser139 of human gamma H2A.X

Conjugate: Unconjugated

Modification: Phosphorylated