Phospho-IRE1 (Ser724) Polyclonal Antibody-BZ16653

Phospho-IRE1 (Ser724) Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BZ16653-50, BZ16653-100

Product: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Swiss-Prot: O75460

Host: Rabbit

Reactivity: Human

Applications: WB

All Applications: WB: 1/500-1/1000

Background: Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of Phospho-IRE1 in K562Lysates treated with AP; Untreated K562Lysates using Phospho-IRE1 antibody.

Bioworld Molecular Weight: Calculated MW: 110 kDa; Observed MW: 110 kDa

Specificity: IgG

Alternative Name: ERN1; IRE1; Serine/threonine-protein kinase/endoribonuclease IRE1; Endoplasmic reticulum-to-nucleus signaling 1; Inositol-requiring protein 1; hIRE1p; Ire1-alpha; IRE1a

Immunogen: A synthesized peptide derived from human Phospho-IRE1 (S724)

Conjugate: Unconjugated

Modification: Phosphorylated