Phospho-JAK2/3 (Tyr966/939) Polyclonal Antibody-BZ16115

Phospho-JAK2/3 (Tyr966/939) Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BZ16115-50, BZ16115-100

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Swiss-Prot: O60674/P52333

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, ELISA

All Applications: WB: 1/500-1/1000 ELISA: 1/10000

Background: Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: IgG

Bioworld Molecular Weight: Calculated MW: 131 kDa; Observed MW: 120-130 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of Phospho-JAK2/3 in mouse liver, hela , mouse brain lysates using Phospho-JAK2/3 antibody., Western blot analysis of Phospho-JAK2/3 in hela lysates using Phospho-JAK2/3 antibody.

Alternative Name: Tyrosine-protein kinase JAK2/JAK3 (EC 2.7.10.2; Janus kinase 2/Janus kinase 3; JAK-2/JAK-3)

Immunogen: Synthesized Phospho peptide derived from human JAK2/3.at AA range: T966

Conjugate: Unconjugated

Modification: Phosphorylated