Phospho-JAK2 (Tyr1007) Polyclonal Antibody-BZ16410

Phospho-JAK2 (Tyr1007) Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BZ16410-50, BZ16410-100

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Swiss-Prot: O60674

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB,IHC-P,ELISA

All Applications: WB: 1/500-1/1000 IHC: 1/50-1/100 ELISA: 1/10000

Background: Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of Phospho-JAK2 in NIH3T3Lysates using Phospho-JAK2 antibody.

Bioworld Molecular Weight: Calculated MW: 131 kDa; Observed MW: 131 kDa

Specificity: IgG

Alternative Name: JAK2; Tyrosine-protein kinase JAK2; Janus kinase 2; JAK-2

Immunogen: The antiserum was produced against synthesized peptide derived from human JAK2 around the phosphorylation site of Tyr1007. AA range:981-1030

Conjugate: Unconjugated

Modification: Phosphorylated