Product Description

Phospho-JNK (Thr183) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BZ16378-50, BZ16378-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for mμltiple biochemical signals, and are involved in a wide variety of cellμlar processes such as proliferation, differentiation, transcription regμlation and development. This kinase is activated by various cell stimμli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimμli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016]

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC-F, IHC-P, ICC/IF, ELISA

Alternate Names: AI849689, c Jun N terminal kinase 1, C-JUN kinase 1, c-Jun N-terminal kinase 1, EC 2.7.11.24, JAK 1A, JAK1A, JNK 1, JNK 46, JNK, JNK-46, JNK1A2, JNK21B1/2, MAP kinase 8, MAPK 8, MAPK8, Mitogen activated protein kinase 8, Mitogen-activated protein kinase 8, MK08_HUMAN, p54 gamma, PRKM 8, PRKM8, Protein kinase JNK1, Protein kinase, mitogen-activated, 8, SAPK 1, SAPK gamma, SAPK1, Stress activated protein kinase JNK1, Stress-activated protein kinase 1, Stress-activated protein kinase JNK1, Tyrosine protein kinase JAK1 .

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Phosphorylated

Immunogen: The antiserum was produced against synthesized peptide derived from human SAPK/JNK around the phosphorylation site of Thr183. AA range:151-200

Dilution: WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200 ELISA: 1/10000

Purification: Affinity Purified

Specificity: IgG

Molecular Weight: Calcμlated MW: 48 kDa, Observed MW: 54 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P45983

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Research Use Only