Product Description

Phospho-KCNQ2/3/4/5 (Thr217/Thr246/Thr223/Thr251) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BZ16487-50, BZ16487-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regμlation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convμlsant drug. Defects in KCNQ2 are a cause of benign familial neonatal convμlsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: IHC-P, ELISA

Alternate Names: KCNQ2, Potassium voltage-gated channel subfamily KQT member 2, KQT-like 2, Neuroblastoma-specific potassium channel subunit alpha KvLQT2, Voltage-gated potassium channel subunit Kv7.2, KCNQ3, Potassium voltage-gated channel subfamily KQT me

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Phosphorylated

Immunogen: The antiserum was produced against synthesized peptide derived from human Kv7.3/KCNQ3 around the phosphorylation site of Thr246. AA range:191-240

Dilution: IHC: 1/50-1/100 ELISA: 1/10000

Purification: Affinity Purified

Specificity: IgG

Molecular Weight: -

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: O43526/O43525/P56696/Q9NR82

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Research Use Only