Phospho-LRP6 (Thr1479) Polyclonal Antibody Size: 100μl Catalogue Number: BS65913-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regμlation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regμlated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined Category: Primary Antibody Reactivity: Human, Mouse, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig Host: Rabbit Applications: FCM Alternate Names: LRP6 (Phospho-Thr1479), LRP6 (Phospho-T1479), p-LRP6 (Thr1479), p-LRP6 (T1479), ADCAD2, C030016K15Rik, Cd, FLJ90062, FLJ90421, Low density lipoprotein receptor related protein 6, LRP6_HUMAN, Low-density lipoprotein receptor-related protein 6, low-density lipoprotein receptor-related protein 6 precursor, LRP-6. Clonality: Polyclonal Conjugate: Unconjugated Modification: Phosphorylation Immunogen: KLH conjugated Synthesised phosphopeptide derived from human LRP6 around the phosphorylation site of Thr1479:KG(p-T)YF Dilution: Flow-Cyt=0.2ug/test Purification: affinity purified by Protein A Specificity: Phospho-LRP6 (Thr1479) Polyclonal Antibody detects endogenous levels of LRP6 protein only when phosphorylated at Thr1479. Molecular Weight: 175kDa Pathway: Regμlation of Microtubμle Dynamics, Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. SwissProt: O75581 Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Research Use Only