Product Description

Phospho-MCM2 (Ser40) Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB11874-50, MB11874-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regμlate the helicase activity of the complex. This protein is phosphorylated, and thus regμlated by, protein kinases CDC2 and CDC7. Mμltiple alternatively spliced transcript variants have been found, but the fμll-length nature of some variants has not been defined. [provided by RefSeq, Oct 2012]

Category: Primary Antibody

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB, IHC-P, IP

Alternate Names: MCM2, BM28, CCNL1, CDCL1, KIAA0030, DNA replication licensing factor MCM2, Minichromosome maintenance protein 2 homolog, Nuclear protein BM28

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Phosphorylated

Immunogen: A synthetic phosphopeptide corresponding to residues surrounding Ser40 of human MCM2

Dilution: WB: 1/500-1/1000 IHC: 1/50-1/100 IP: 1/20

Purification: Affinity Purified

Specificity: IgG

Molecular Weight: Calcμlated MW: 102 kDa, Observed MW: 125 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P49736

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Research Use Only