Phospho-MEK4 (Ser80) Monoclonal Antibody-MB11875

Phospho-MEK4 (Ser80) Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB11875-50, MB11875-100

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Swiss-Prot: P45985

Host: Rabbit

Reactivity: Human

Applications: WB, IP,

All Applications: WB: 1/500-1/1000 IP: 1/20

Background: This gene encodes a member of the mitogen-activated protein kinase (MAPK) family. Members of this family act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. They form a three-tiered signaling module composed of MAPKKKs, MAPKKs, and MAPKs. This protein is phosphorylated at serine and threonine residues by MAPKKKs and subsequently phosphorylates downstream MAPK targets at threonine and tyrosine residues. A similar protein in mouse has been reported to play a role in liver organogenesis. A pseudogene of this gene is located on the long arm of chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: IgG

Bioworld Molecular Weight: Calculated MW: 44 kDa; Observed MW: 44 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of Phospho-MEK4/MKK4 in 3T3 lysates using Phospho-MEK4 antibody., Western blot analysis of Phospho-MEK4/MKK4 in A549, MCF-7, U251 lysates using Phospho-MEK4/MKK4 antibody.

Alternative Name: MAP2K4; JNKK1; MEK4; MKK4; PRKMK4; SEK1; SERK1; SKK1; Dual specificity mitogen-activated protein kinase kinase 4; MAP kinase kinase 4; MAPKK 4; JNK-activating kinase 1; MAPK/ERK kinase 4; MEK 4; SAPK/ERK kinase 1; SEK1; Stress-activated pro

Immunogen: A synthetic phosphopeptide corresponding to residues surrounding Ser80 of human MEK4/MKK4

Conjugate: Unconjugated

Modification: Phosphorylated