Product Description

phospho-MLKL (S358) Mouse Monoclonal Antibody (6B4)

Sizes: 50μL, 100μL

Catalogue Numbers: RA11844-50, RA11844-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: mixed lineage kinase domain like (MLKL) Homo sapiens This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015],

Reactivity: Human

Host: Mouse

Applications: IHC-p, IF(paraffin section)

Alternate Names: MLKL

Clonality: Monoclonal

Dilution: Western Blot: 1/500 - 1/2000.IHC-p:1:50-200. Not yet tested in other applications.

Storage: -20°C/1 year

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Human Gene ID: 197259

Protein Molecular Weight（KDa): 54

Molecular Weight: 54

Research Use Only