Phospho-MSK1 (Ser376) Monoclonal Antibody-MB11239

Phospho-MSK1 (Ser376) Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB11239-50, MB11239-100

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Swiss-Prot: O75582

Host: Rabbit

Reactivity: Human, Rat

Applications: WB, IHC-P, IP,

All Applications: WB: 1/500-1/1000 IHC: 1/50-1/100 IP: 1/20

Background: Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and Et V1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: IgG

Bioworld Molecular Weight: Calculated MW: 90 kDa; Observed MW: 90 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of Phospho-MSK1 in rat brain lysates using Phospho-MSK1 antibody., Western blot analysis of Phospho-MSK1 in K562 lysates using Phospho-MSK1 antibody., Immunohistochemistry analysis of paraffin-embedded Human breast cancer using MSK1 antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Alternative Name: RPS6KA5; MSK1; Ribosomal protein S6 kinase alpha-5; S6K-alpha-5; 90 kDa ribosomal protein S6 kinase 5; Nuclear mitogen- and stress-activated protein kinase 1; RSK-like protein kinase; RSKL

Immunogen: A synthetic phosphopeptide corresponding to residues surrounding Ser376 of human MSK1

Conjugate: Unconjugated

Modification: Phosphorylated