Phospho-mTOR (Ser2448) Monoclonal Antibody-MB11248

Phospho-mTOR (Ser2448) Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB11248-50, MB11248-100

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Swiss-Prot: P42345

Host: Rabbit

Reactivity: Human, Mouse

Applications: WB, IHC-P

All Applications: WB: 1/500-1/1000 IHC: 1/50-1/100

Background: An atypical kinase belonging to the PIKK family of kinases. Controls cell growth through protein synthesis regulation. Downstream of PI3K/Akt pathway and required for cell survival. Acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: IgG

Bioworld Molecular Weight: Calculated MW: 289 kDa; Observed MW: 289 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of Phospho-mTOR in Hela, Hela+EGF lysates using Phospho-mTOR antibody., Western blot analysis of mTOR in 3t3 lysates using mTOR antibody., Immunohistochemistry analysis of paraffin-embedded Human lung cancer using Phospho-mTOR antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Alternative Name: MTOR; FRAP; FRAP1; FRAP2; RAFT1; RAPT1; Serine/threonine-protein kinase mTOR; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP12-rapamycin complex-associated protein; Mammalian target of rapamycin; mTOR; Mechanistic tar

Immunogen: A synthetic phosphopeptide corresponding to residues surrounding Ser2448 of human mTOR

Conjugate: Unconjugated

Modification: Phosphorylated