Product Description

Phospho-p107 (Thr369) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BZ16479-50, BZ16479-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Key regμlator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particμlar, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. Forms a complex with adenovirus E1A and with SV40 large T antigen. May bind and modμlate functionally certain cellμlar proteins with which T and E1A compete for pocket binding. May act as a tumor suppressor.

Category: Primary Antibody

Reactivity: Human, Mouse

Host: Rabbit

Applications: IHC-P, ELISA

Alternate Names: PRB1, p107, CP107

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Phosphorylated

Immunogen: The antiserum was produced against synthesized peptide derived from human RBL1 around the phosphorylation site of Thr369. AA range:335-384

Dilution: IHC: 1/50-1/100 ELISA: 1/10000

Purification: Affinity Purified

Specificity: IgG

Molecular Weight: -

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P28749

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Research Use Only