Phospho-p107 (Thr369) Polyclonal Antibody-BZ16479

Phospho-p107 (Thr369) Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BZ16479-50, BZ16479-100

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Swiss-Prot: P28749

Host: Rabbit

Reactivity: Human, Mouse

Applications: IHC-P, ELISA

All Applications: IHC: 1/50-1/100 ELISA: 1/10000

Background: Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. Forms a complex with adenovirus E1A and with SV40 large T antigen. May bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. May act as a tumor suppressor.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: IgG

Bioworld Molecular Weight: -

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: EnzymeLinked Immunosorbent Assay for Immunogen Phospho-peptide and NonPhospho-peptide , using RBL1 (Phospho-Thr36antibody, Immunohistochemical analysis of paraffin-embedded Human tonsils using Phospho-p107 antibody. Sample with blocking peptide on the right. High-pressure and temperature Sodium Citrate pH 6. 0 was used for antigen retrieval.

Alternative Name: PRB1; p107; CP107

Immunogen: The antiserum was produced against synthesized peptide derived from human RBL1 around the phosphorylation site of Thr369. AA range:335-384

Conjugate: Unconjugated

Modification: Phosphorylated