Product Description

phospho-p53BP1 (Ser25 + Ser29) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS65621-50, BS65621-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: p53 binding protein 1 (53BP1) plays a critical role in tumor suppression and is a putative substrate of ATM kinase. Upon DNA damage, it is phosphorylated and relocalizes to the presumptive sites of damage, specifically, double strand breaks. This also suggests a role in DNA repair, maintaining genomic stability.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit

Host: Rabbit

Applications: IHC-P

Alternate Names: 53BP1 (phospho S25), p-53BP1 (phospho S25) , 53BP1 (Phospho-Ser25/29), 53BP1 (Phospho-S25/S29), phospho-p53BP1(Ser25/Ser29), P-53BP1 (Ser25/29), 53 BP1, FLJ41424, MGC138366, p202, p53 binding protein 1, p53 BP1, p53BP1, TP53 BP1, TP53BP1, Tumor protein 53 binding protein 1, Tumor protein p53 binding protein 1, Tumor suppressor p53 binding protein 1, TP53B_HUMAN, tumor protein 53-binding protein, 1.

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Phosphorylation

Immunogen: KLH conjugated Synthesised phosphopeptide derived from human p53BP1 around the phosphorylation site of Ser25/29:ED(p-S)QPE(p-S)QV

Dilution: IHC-P=1:100-500

Purification: affinity purified by Protein A

Specificity: phospho-p53BP1 (Ser25 + Ser29) Polyclonal Antibody detects endogenous levels of phospho-p53BP1 protein only when phosphorylated at Ser25 + Ser29.

Molecular Weight: 213kD

Pathway: Cell Cycle G2 M DNA Damage Signaling Pathway,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q12888

Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Research Use Only