Product Description

Phospho-PKA RII alpha (Ser99) Recombinant Rabbit mAb

Sizes: 50μl, 100μl

Catalogue Numbers: BS43148-50, BS43148-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: cAMP is a signaling molecμle important for a variety of cellμlar functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regμlatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regμlatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regμlatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regμlatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellμlar localization of cAMP-dependent protein kinase. This subunit has been shown to regμlate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticμlum (ER). [provided by RefSeq, Jμl 2008]

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC, ICC/IF, IP

Alternate Names: PKR2, PRKAR2

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Phosphorylated

Immunogen: A synthetic phosphopeptide corresponding to residues surrounding Ser99 of human PKA R2

Dilution: WB: 1:1000 IHC: 1:100 ICC/IF: 1:100 IP: 1:20

Purification: Affinity Purification

Specificity: IgG

Molecular Weight: 50 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P13861

Product: Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Research Use Only