Phospho-PML Protein (Ser518) Monoclonal Antibody-MB11885

Phospho-PML Protein (Ser518) Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB11885-50, MB11885-100

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Swiss-Prot: P29590

Host: Rabbit

Reactivity: Human

Applications: WB, IHC-P

All Applications: WB: 1/500-1/1000 IHC: 1/50-1/100

Background: Regulates RB1 phosphorylation and activity. Required for normal development of the brain cortex during embryogenesis. Can sequester herpes virus and varicella virus proteins inside PML bodies, and thereby inhibit the formation of infectious viral particles. Regulates phosphorylation of ITPR3 and plays a role in the regulation of calcium homeostasis at the endoplasmic reticulum (By similarity). Regulates transcription activity of ELF4.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: IgG

Bioworld Molecular Weight: Calculated MW: 98 kDa; Observed MW: 98,117 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of Phospho-PML Protein in A549, HL-60, U2OS lysates using Phospho-PML Protein antibody., Immunohistochemistry analysis of paraffin-embedded Human breast cancer using PML Protein antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Alternative Name: PML; MYL; RNF71; TRIM19; Protein PML; Promyelocytic leukemia protein; RING finger protein 71; Tripartite motif-containing protein 19

Immunogen: A synthetic phosphopeptide corresponding to residues surrounding Ser518 of human PML Protein

Conjugate: Unconjugated

Modification: Phosphorylated